| 5 Nov | IL Wesleyan 48 | at | S Illinois 76 | vs ND1 | ||
| 8 Nov | S Illinois 72 | vs | UT San Antonio 60 | Kissimmee, FL | vs CUSA | |
| 9 Nov | Delaware 56 | vs | S Illinois 54 | Kissimmee, FL | vs CAA | |
| 10 Nov | Oakland 61 | vs | S Illinois 52 | Kissimmee, FL | vs HL | |
| 16 Nov | San Francisco 76 | at | S Illinois 60 | vs WCC | ||
| 19 Nov | S Illinois 66 | at | Murray St 79 | at OVC | ||
| 26 Nov | NC Central 48 | at | S Illinois 64 | vs MEAC | ||
| 1 Dec | S Illinois 60 | at | St Louis 69 | at A10 | ||
| 4 Dec | Norfolk St 59 | at | S Illinois 76 | vs MEAC | ||
| 7 Dec | S Illinois 69 | at | Southern Miss 72 | at CUSA | ||
| 15 Dec | S Illinois 48 | at | Missouri 64 | at SEC | ||
| 18 Dec | Hampton 53 | at | S Illinois 75 | vs BSo | ||
| 21 Dec | SE Missouri St 45 | at | S Illinois 64 | vs OVC | ||
| 30 Dec | S Illinois 56 | at | Indiana St 68 | |||
| 4 Jan | Illinois St 55 | at | S Illinois 67 | |||
| 7 Jan | Valparaiso 50 | at | S Illinois 63 | |||
| 11 Jan | S Illinois 48 | at | Bradley 67 | |||
| 16 Jan | S Illinois 48 | at | Loyola-Chicago 64 | |||
| 19 Jan | Drake | at | S Illinois | |||
| 22 Jan | Northern Iowa | at | S Illinois | |||
| 25 Jan | S Illinois | at | Illinois St | |||
| 29 Jan | Loyola-Chicago | at | S Illinois | |||
| 1 Feb | S Illinois | at | Drake | |||
| 5 Feb | S Illinois | at | Evansville | |||
| 8 Feb | Missouri St | at | S Illinois | |||
| 12 Feb | S Illinois | at | Valparaiso | |||
| 15 Feb | Bradley | at | S Illinois | |||
| 20 Feb | Evansville | at | S Illinois | |||
| 23 Feb | S Illinois | at | Northern Iowa | |||
| 26 Feb | Indiana St | at | S Illinois | |||
| 29 Feb | S Illinois | at | Missouri St |
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